4-nitro-N-ethylphthalimide → 5-Amino-2-ethylisoindoline-1,3-dione
반응식
[CH2:1]([N:3]1[C:7](=[O:8])[C:6]2=[CH:9][C:10]([N+:13]([O-])=O)=[CH:11][CH:12]=[C:5]2[C:4]1=[O:16])[CH3:2]>[Ni].C(O)C>[NH2:13][C:10]1[CH:9]=[C:6]2[C:7](=[O:8])[N:3]([CH2:1][CH3:2])[C:4](=[O:16])[C:5]2=[CH:12][CH:11]=1참가 물질
4
실험 절차
N-Ethyl-4-nitrophthalimide (28.0 g.) is hydrogenated in 400 ml. of ethanol and in the presence of Raney nickel catalyst (10 g.) at 100°C. and 1500 psi. pressure. The reaction mixture is filtered to remove the catalyst and the filtrate is concentrated to yield the product, 4-amino-N-ethylphthalimide, which is recrystallized from methanol-water mixture. It melts at 169°-171°C.
후처리
- customat 100°C.
- filtrationThe reaction mixture is filtered
- customto remove the catalyst
- concentrationthe filtrate is concentrated
출처 및 근거
- ORD 기록
- ord-df09496caaff4101b31cd073e0fd018d
- 출처 데이터셋
- uspto-grants-1976_09
- 특허 번호
- US03980634
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