Hydrazine hydrate (1:1) → 3-(4'-Fluoro-4-biphenylyl)-3-methyl-pyrazolidin-5-one

HRID 1576419노트

반응식

HRID 1576419 반응식
C([O:3][C:4](=O)[CH2:5][C:6]([C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)=[CH:11][CH:10]=1)(O)[CH3:7])C.O.[NH2:24][NH2:25]>>[F:21][C:18]1[CH:19]=[CH:20][C:15]([C:12]2[CH:13]=[CH:14][C:9]([C:6]3([CH3:7])[CH2:5][C:4](=[O:3])[NH:25][NH:24]3)=[CH:10][CH:11]=2)=[CH:16][CH:17]=1

참가 물질

3

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 540173473-(4'-Fluoro-4-biphenylyl)-3-hydroxybutyric acid ethyl ester

생성물 1

HCID 215126753-(4'-Fluoro-4-biphenylyl)-3-methyl-pyrazolidin-5-one

실험 절차

A mixture of 30.2 g of 3-(4'-fluoro-4-biphenylyl)-3-hydroxybutyric acid ethyl ester and 25 g of 100% strength hydrazine hydrate is heated at 100° for 4 hours. The mixture is worked up in the usual manner to give 3-(4'-fluoro-4-biphenylyl)-3-methyl-pyrazolidin-5-one, m.p. 194°-196 °.

후처리

  1. temperatureis heated at 100° for 4 hours

출처 및 근거

ORD 기록
ord-aea07c6ead2c467baca32693afad0c1c
출처 데이터셋
uspto-grants-1976_09
특허 번호
US03980795

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