Hydrochloric Acid → 3alpha-Hydroxy-21-morpholino-5alpha-pregnane-11,20-dione hydrochloride

HRID 1576777노트

반응식

HRID 1576777 반응식
[OH:1][C@@H:2]1[CH2:27][CH2:26][C@@:25]2([CH3:28])[C@@H:4]([CH2:5][CH2:6][C@@H:7]3[C@@H:24]2[C:23](=[O:29])[CH2:22][C@@:21]2([CH3:30])[C@H:8]3[CH2:9][CH2:10][C@@H:11]2[C:12](=[O:20])[CH2:13][N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[CH2:3]1.[ClH:31]>C(O)C>[ClH:31].[OH:1][C@@H:2]1[CH2:27][CH2:26][C@@:25]2([CH3:28])[C@@H:4]([CH2:5][CH2:6][C@@H:7]3[C@@H:24]2[C:23](=[O:29])[CH2:22][C@@:21]2([CH3:30])[C@H:8]3[CH2:9][CH2:10][C@@H:11]2[C:12](=[O:20])[CH2:13][N:14]2[CH2:15][CH2:16][O:17][CH2:18][CH2:19]2)[CH2:3]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 867340213alpha-Hydroxy-21-morpholino-5alpha-pregnane-11,20-dione

생성물 1

HCID 867340253alpha-Hydroxy-21-morpholino-5alpha-pregnane-11,20-dione hydrochloride

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 3α-hydroxy-21-morpholino-5α-pregnane-11,20-dione (104.14 mg., 0.25 mmole) in ethanol (4 ml.) was treated with 0.1N hydrochloric acid (2.5 ml., 0.25 mmole). The solution was evaporated in vacuo and then treated with water (5 ml.). The undissolved solid (8.4 mg.) was removed by filtration and the filtrate was made up to 9.6 ml. with distilled water to give a 1% aqueous solution of the title compound.

후처리

  1. customThe solution was evaporated in vacuo
  2. additiontreated with water (5 ml.)
  3. customThe undissolved solid (8.4 mg.) was removed by filtration

출처 및 근거

ORD 기록
ord-740cbae19b3341ea8e4cd3ca7830c7af
출처 데이터셋
uspto-grants-1976_09
특허 번호
US03983111

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