Acetic Anhydride → 2-[2-(Acetyloxy)phenyl][1,2]oxazolo[2,3-a]pyridin-8-ium bromide

반응식

[Br-:1].[OH:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[O:17][N+:12]2=[CH:13][CH:14]=[CH:15][CH:16]=[C:11]2[CH:10]=1.[C:18](OC(=O)C)(=[O:20])[CH3:19]>>[Br-:1].[C:18]([O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[O:17][N+:12]2=[CH:13][CH:14]=[CH:15][CH:16]=[C:11]2[CH:10]=1)(=[O:20])[CH3:19]

참가 물질

반응물 2

HCID 7918Acetic Anhydride

HCID 123521782-(2-Hydroxyphenyl)[1,2]oxazolo[2,3-a]pyridin-8-ium bromide

생성물 1

HCID 123521952-[2-(Acetyloxy)phenyl][1,2]oxazolo[2,3-a]pyridin-8-ium bromide수율 73%

실험 절차

2-(2-Hydroxyphenyl)isoxazolo[ 2,3-a]pyridinium bromide from Example 1 (5.0 g) is refluxed in acetic anhydride (40 ml) under nitrogen for 60-90 minutes. The solution is cooled, and the solvent is evaporated. The oily residue is diluted with ethyl acetate to crystallize the product. Recrystallization from isopropanol gives gray-white crystals (4.16 g, 73%) m.p. 198°-201°C.

후처리

temperatureThe solution is cooled
customthe solvent is evaporated
additionThe oily residue is diluted with ethyl acetate
customto crystallize the product
customRecrystallization from isopropanol

출처 및 근거

ORD 기록: ord-abb585ea471340dbbe828b3d89a2ce6b
출처 데이터셋: uspto-grants-1976_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US03983237

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