Thionyl Chloride → 4-(Pyrid-4-yl)butyroyl chloride hydrochloride

HRID 1577847노트

반응식

HRID 1577847 반응식
[ClH:1].[N:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][C:11]([OH:13])=O)=[CH:4][CH:3]=1.S(Cl)([Cl:16])=O>ClC(Cl)C.CN(C)C=O>[ClH:16].[N:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][C:11]([Cl:1])=[O:13])=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 24386Thionyl ChlorideHCID 467359454-Pyridin-4-YL-butyric acid hydrochloride

생성물 1

HCID 205699404-(Pyrid-4-yl)butyroyl chloride hydrochloride

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 63651,1-Dichloroethane용매

실험 절차

4-(Pyrid-4-yl)butyric acid hydrochloride (ca. 35 g) in dichloroethane (250 ml) and dimethylformamide (0.5 ml) was treated with thionyl chloride (100 ml). The vigorous exothermic reaction was allowed to subside and then the mixture was heated under reflux for 10 minutes, followed by evaporation to dryness in vacuo to give crude 4-(pyrid-4-yl)butyroyl chloride hydrochloride.

후처리

  1. customThe vigorous exothermic reaction
  2. temperaturethe mixture was heated
  3. temperatureunder reflux for 10 minutes
  4. customfollowed by evaporation to dryness in vacuo

출처 및 근거

ORD 기록
ord-a207383eb217417cae2155479e9acfab
출처 데이터셋
uspto-grants-1981_09
특허 번호
US04289772

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