Hydrochloric Acid → HCID 178505637, 화합물

HRID 1578526노트

반응식

HRID 1578526 반응식
[OH-].[K+].[CH:3]([NH:5][NH:6][C:7]([NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[F:16])=[S:8])=O.Cl>O>[F:16][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[N:9]1[CH:3]=[N:5][N:6]=[C:7]1[SH:8]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 2390670Hydrazinecarbothioamide, N-(2-fluorophenyl)-2-formyl-

생성물 1

HCID 178505637HCID 178505637, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

One and one-tenth grams (20 mmoles) of potassium hydroxide were dissolved in 50 ml. of water. 1-Formyl-4-(2-fluorophenyl)thiosemicarbazide, 3.5 g. (16.5 mmoles), was dissolved in the basic solution by warming on the steam bath until solution was completed. The heating was continued for one hour. The cooled reaction mixture was poured into a dilute solution of hydrochloric acid. The insoluble product was recovered from the acidic solution by filtration. The product was washed with water, collected and dried. The yield was 2.5 g. of 4-(2-fluorophenyl)-1,2,4-triazole-3-thiol, m.p. about 166°-167°C.

후처리

  1. dissolution(16.5 mmoles), was dissolved in the basic solution
  2. temperatureby warming on the steam bath until solution
  3. customThe cooled reaction mixture
  4. filtrationThe insoluble product was recovered from the acidic solution by filtration
  5. washThe product was washed with water
  6. customcollected
  7. customdried

출처 및 근거

ORD 기록
ord-16a0bf1041d64cea8a7aee23d4da0988
출처 데이터셋
uspto-grants-1976_02
특허 번호
US03937713

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