Ethanethiol → HCID 54553130, 화합물

HRID 1578855노트

반응식

HRID 1578855 반응식
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[N:11]=[CH:10][CH:9]=[CH:8][C:6]=2[N:7]=1.[OH-].[Na+].[CH2:15]([SH:17])[CH3:16]>CC(C)=O.O>[Cl:1][C:2]1[N:3]=[C:4]([S:17][CH2:15][CH3:16])[C:5]2[N:11]=[CH:10][CH:9]=[CH:8][C:6]=2[N:7]=1

참가 물질

6

반응물 3

HCID 6343EthanethiolHCID 14798Sodium HydroxideHCID 119580532,4-DICHLOROPYRIDO[3,2-D]PYRIMIDINE

생성물 1

HCID 54553130HCID 54553130, 화합물수율 65%

시약·촉매·용매 2

HCID 180Acetone용매HCID 962Water용매2회

실험 절차

A suspension of 15 gm (0.075 mol) of 2,4-dichloropyrido[3,2-d]pyrimidine in 100 ml of acetone at -40°C was admixed with a solution of 3.2 gm (0.08 mol) of sodium hydroxide and 4.9 gm (5.8 ml) of ethylmercaptan in 25 ml of water, and the mixture was stirred for two hours at room temperature. Thereafter, 200 ml of water were added to the reaction mixture, and the precipitate formed thereby was collected and recrystallized from petroleum ether, yielding 11.0 gm (65% of theory) of 2-chloro-4-ethylmercapto-pyrido[3,2-d]pyrimidine, m.p. 101°-103°C.

후처리

  1. customthe precipitate formed
  2. customthereby was collected
  3. customrecrystallized from petroleum ether

출처 및 근거

ORD 기록
ord-a75d9329604c4255b2c6c06a9e159a1c
출처 데이터셋
uspto-grants-1976_02
특허 번호
US03939268

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