1-Methylpiperazine → 4-Chloro-2-(4-methoxyphenyl)-6-(4-methyl-1-piperazinyl)-pyrimidine
반응식
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=2)[N:3]=1.[CH3:17][N:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1>C(O)C>[Cl:8][C:6]1[CH:7]=[C:2]([N:21]2[CH2:22][CH2:23][N:18]([CH3:17])[CH2:19][CH2:20]2)[N:3]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=2)[N:5]=1참가 물질
4
실험 절차
Employing the procedure of Example XX, 7.7 g. of 4,6-dichloro-2-(4-methoxyphenyl)-pyrimidine is reacted with 6.0 g. of N-methylpiperazine in 45 ml. of absolute ethanol to afford 4-chloro-2-(4-methoxyphenyl)-6-(4-methyl-1-piperazinyl)-pyrimidine, m.p. 88°-90°C.
출처 및 근거
- ORD 기록
- ord-f74116e841f14d2da66e7e10fbe1d0c2
- 출처 데이터셋
- uspto-grants-1976_02
- 특허 번호
- US03940395
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