Sodium Hydroxide → 4-[4-(Oxiran-2-ylmethoxy)phenyl]-1,2,3-thiadiazole

HRID 1579050

반응식

HRID 1579050 반응식
[OH-].[Na+].[OH:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[N:12][S:13][CH:14]=2)=[CH:6][CH:5]=1.[CH2:15]([CH:17]1[O:19][CH2:18]1)Br>O>[O:19]1[CH2:18][CH:17]1[CH2:15][O:3][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[N:11]=[N:12][S:13][CH:14]=2)=[CH:8][CH:9]=1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 18430EpibromohydrinHCID 27968604-(1,2,3-Thiadiazol-4-Yl)Phenol

생성물 1

HCID 27371034-[4-(Oxiran-2-ylmethoxy)phenyl]-1,2,3-thiadiazole

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a solution of 0.112 g. of sodium hydroxide in 10 ml. of water is added 0.499 g. of 4-(4-hydroxyphenyl)1,2,3-thiadiazole and to the resulting solution is added dropwise, under stirring, 0.66 ml. of epibromohydrin, in a 5 minute period. The reaction mixture is stirred for 48 hours and extracted several times with ethyl acetate. The combined organic extracts are washed with water to neutrality, dried over anhydrous sodium sulfate and evaporated to dryness under vacuo. The semisolid residue is crystallized from methylene chloride-hexane to yield the pure 4-[4(2,3-epoxypropoxy)phenyl] 1,2,3-thiadiazole.

후처리

  1. stirringThe reaction mixture is stirred for 48 hours
  2. extractionextracted several times with ethyl acetate
  3. washThe combined organic extracts are washed with water to neutrality
  4. dry with materialdried over anhydrous sodium sulfate
  5. customevaporated to dryness under vacuo
  6. customThe semisolid residue is crystallized from methylene chloride-hexane

출처 및 근거

ORD 기록
ord-f391237350f5492a937ff261322763b3
출처 데이터셋
uspto-grants-1976_02
특허 번호
US03940407

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