Potassium Permanganate → HCID 12898485, 화합물

HRID 1579392노트

반응식

HRID 1579392 반응식
[CH3:1][CH:2]([CH3:20])[CH:3]([C:5]1[CH:6]=[CH:7][C:8]2[O:17][C:12]3=[N:13][CH:14]=[CH:15][CH:16]=[C:11]3[C:10](=[O:18])[C:9]=2[CH:19]=1)[OH:4].[Mn]([O-])(=O)(=O)=O.[K+]>CC(C)=O>[C:3]([C:5]1[CH:6]=[CH:7][C:8]2[O:17][C:12]3=[N:13][CH:14]=[CH:15][CH:16]=[C:11]3[C:10](=[O:18])[C:9]=2[CH:19]=1)(=[O:4])[CH:2]([CH3:20])[CH3:1]

참가 물질

4

반응물 2

HCID 516875Potassium PermanganateHCID 13207925HCID 13207925, 화합물

생성물 1

HCID 12898485HCID 12898485, 화합물

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 2.7 g of 2-methyl-1-(5-oxo-5H-[1]benzopyrano[2,3-b]pyridin-7-yl)-1-propanol, 60 ml of acetone and 1.5 g of potassium permanganate is refluxed for 6 hours. The reaction mixture is filtered, and the residue is washed thoroughly was chloroform. The filtrate and washings are concentrated, and the residue is purified by column chromatography on silica gel with chloroform as eluent, and further by recrystallization from ethanol to give 7-isobutyryl-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine melting at 155°-156°C.

후처리

  1. temperatureis refluxed for 6 hours
  2. filtrationThe reaction mixture is filtered
  3. washthe residue is washed thoroughly was chloroform
  4. concentrationThe filtrate and washings are concentrated
  5. customthe residue is purified by column chromatography on silica gel with chloroform as eluent
  6. customfurther by recrystallization from ethanol

출처 및 근거

ORD 기록
ord-a725107989af4e2292a9931ddceeaf04
출처 데이터셋
uspto-grants-1976_01
특허 번호
US03931199

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