Potassium Permanganate → HCID 12898485, 화합물

HRID 1579393노트

반응식

HRID 1579393 반응식
[Mn]([O-])(=O)(=O)=[O:2].[K+].[N:7]1[CH:12]=[CH:11][CH:10]=[C:9]2[CH2:13][C:14]3[CH:20]=[C:19]([CH:21]([OH:25])[CH:22]([CH3:24])[CH3:23])[CH:18]=[CH:17][C:15]=3[O:16][C:8]=12>CC(C)=O>[C:21]([C:19]1[CH:18]=[CH:17][C:15]2[O:16][C:8]3=[N:7][CH:12]=[CH:11][CH:10]=[C:9]3[C:13](=[O:2])[C:14]=2[CH:20]=1)(=[O:25])[CH:22]([CH3:23])[CH3:24]

참가 물질

4

반응물 2

HCID 516875Potassium PermanganateHCID 21568412HCID 21568412, 화합물

생성물 1

HCID 12898485HCID 12898485, 화합물

시약·촉매·용매 1

HCID 180Acetone용매

반응 조건

온도
20 °C

실험 절차

11 g of potassium permanganate is added in small portions to a solution of 6 g of 1-(5H-[1]benzopyrano[2,3-b]pyridin-7-yl)-2-methyl-1 -propanol in 160 ml of acetone, and the mixture is stirred at 20°C for 3 hours. The reaction mixture is filtered, and the residue is washed thoroughly with chloroform. The filtrate and washings are concentrated, and the residue is purified by column chromatography on silica gel with chloroform as eluent, and further by recrystallization from acetone to give 7-isobutyryl-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine melting at 155°-156°C.

후처리

  1. filtrationThe reaction mixture is filtered
  2. washthe residue is washed thoroughly with chloroform
  3. concentrationThe filtrate and washings are concentrated
  4. customthe residue is purified by column chromatography on silica gel with chloroform as eluent
  5. customfurther by recrystallization from acetone

출처 및 근거

ORD 기록
ord-1f91f159dfe543b1ab0078d1a403e94a
출처 데이터셋
uspto-grants-1976_01
특허 번호
US03931199

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