Propylamine → 2-Ethoxy-4-n-propylamino-thieno[3,4-d]pyrimidine

HRID 1579427노트

반응식

HRID 1579427 반응식
[CH2:1]([O:3][C:4]1[N:5]=[C:6](OCC)[C:7]2[C:8](=[CH:10][S:11][CH:12]=2)[N:9]=1)[CH3:2].[CH2:16]([NH2:19])[CH2:17][CH3:18]>C(O)C>[CH2:1]([O:3][C:4]1[N:5]=[C:6]([NH:19][CH2:16][CH2:17][CH3:18])[C:7]2[C:8](=[CH:10][S:11][CH:12]=2)[N:9]=1)[CH3:2]

참가 물질

4

반응물 2

HCID 7852PropylamineHCID 21568428HCID 21568428, 화합물

생성물 1

HCID 215684642-Ethoxy-4-n-propylamino-thieno[3,4-d]pyrimidine

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 2.3 g (0.01 mole) of 2,4-diethoxy-thieno[3,4-d]pyrimidine and 3.6 g (0.06 mole) of n-propylamine in 50 ml absolute ethyl alcohol is heated under reflux for 10 hours. The solution is then evaporated to dryness. The solid is drained off, washed with water and dried. After recrystallization from toluene, 14 g (59% of theory) of 2-ethoxy-4-n-propylamino-thieno[3,4-d]pyrimidine are obtained. M.P. 140°-142°C.

후처리

  1. temperatureunder reflux for 10 hours
  2. customThe solution is then evaporated to dryness
  3. washwashed with water
  4. customdried
  5. customAfter recrystallization from toluene, 14 g (59% of theory) of 2-ethoxy-4-n-propylamino-thieno[3,4-d]pyrimidine
  6. customare obtained

출처 및 근거

ORD 기록
ord-98122460a0e44fd8860c40a40c6481f6
출처 데이터셋
uspto-grants-1976_01
특허 번호
US03931204

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