Isocyanic acid → 2,5-Bis(2-methylpropyl)-3,6-dimethylpyrazine

HRID 1579679

반응식

HRID 1579679 반응식
[CH3:1][CH:2]([CH3:10])[CH2:3][C:4](=[N:8]O)[C:5](=O)[CH3:6].[CH3:11][CH:12]([CH3:18])[CH2:13][CH2:14][C:15](=O)[CH3:16].[N:19](Cl)=O.N=C=O>[Zn].C(O)(=O)C>[CH3:6][C:5]1[C:4]([CH2:3][CH:2]([CH3:10])[CH3:1])=[N:8][C:15]([CH3:16])=[C:14]([CH2:13][CH:12]([CH3:18])[CH3:11])[N:19]=1

참가 물질

7

반응물 4

HCID 6347Isocyanic acidHCID 80345-Methyl-2-hexanoneHCID 17601Nitrosyl chlorideHCID 714430275-Methyl-3-oximino-2-hexanone

생성물 1

HCID 5854102,5-Bis(2-methylpropyl)-3,6-dimethylpyrazine

시약·촉매·용매 2

HCID 23994Zinc촉매HCID 176Acetic Acid용매

실험 절차

f. 2,5-Dimethyl-3,6-diisobutyl-pyrazine was prepared by first forming 5-methyl-3-oximino-2-hexanone by reacting 5-methyl-2-hexanone with nitrosyl chloride according to the method of BOUVEAULT (loc.cit.). The autocondensation of two moles of the imino-ketone in the presence of zinc and acetic acid [according to the method described in Chimia 11, 310 (1957)] yielded 2,5-dimethyl-3,6-diisobutyl-pyrazine which had a b.p. of 69°-70°C./0.01 mm. Hg.

출처 및 근거

ORD 기록
ord-69cf1dade8e14c57a0dd6c03f4bfb111
출처 데이터셋
uspto-grants-1976_01
특허 번호
US03931245

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