홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Hydrogen Bromide → 4-[(2-Methylhydrazino)-methyl]-benzoic acid [2-hydroxy-3,3,3-trichloropropyl]amide hydrobromide

HRID 1579711
노트
인쇄 미리보기

반응식

HRID 1579711 반응식
C[N:2]([C:24](OCC1C=CC=CC=1)=O)[N:3]([CH2:14][C:15]1[CH:23]=[CH:22][C:18]([C:19](Cl)=[O:20])=[CH:17][CH:16]=1)C(OCC1C=CC=CC=1)=O.C(Cl)Cl.[OH:37][CH:38]([C:41]([Cl:44])([Cl:43])[Cl:42])[CH2:39][NH2:40].[BrH:45]>C(O)(=O)C.O>[BrH:45].[OH:37][CH:38]([C:41]([Cl:44])([Cl:43])[Cl:42])[CH2:39][NH:40][C:19](=[O:20])[C:18]1[CH:17]=[CH:16][C:15]([CH2:14][NH:3][NH:2][CH3:24])=[CH:23][CH:22]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 260Hydrogen BromideHCID 6344Dichloromethane2회HCID 215437Propanol, 3-amino-1-trichloro-HCID 215690594-[(2-Methyl-1,2-dicarbobenzoxy-hydrazino)-methyl]-benzoyl chloride

생성물 1

HCID 1317098904-[(2-Methylhydrazino)-methyl]-benzoic acid [2-hydroxy-3,3,3-trichloropropyl]amide hydrobromide

시약·촉매·용매 2

HCID 176
Acetic Acid
용매
HCID 962Water용매

실험 절차

15.8 g. of 4-[(2-methyl-1,2-dicarbobenzoxy-hydrazino)methyl]-benzoyl chloride were dissolved in 50 ml. of methylene chloride. This solution was added, while stirring, dropwise to a suspension of 12.6 g. of 2-hydroxy-3,3,3-trichloro-propylamine in 150 ml. of methylene chloride. Stirring was continued for 2 hours at room temperature and 30 minutes at 40°, whereupon 50 ml. of water were added thereto. The product was worked up according to Example 3 and treated with hydrogen bromide in glacial acetic acid. The crystalline crude material was recrystallized from ethanol/acetonitrile/ether, yielding 4-[(2-methylhydrazino)-methyl]-benzoic acid [2-hydroxy-3,3,3-trichloropropyl]amide hydrobromide melting at 187°-189° (dec.).

후처리

  1. additionThis solution was added
  2. stirringStirring
  3. customThe crystalline crude material was recrystallized from ethanol/acetonitrile/ether

출처 및 근거

ORD 기록
ord-ad9b02f778a642cdb976f29f13b2393d
출처 데이터셋
uspto-grants-1976_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US03931268

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트