Sodium Hydroxide → HCID 21569669, 화합물

HRID 1579849노트

반응식

HRID 1579849 반응식
[CH2:1]([O:3][C:4]1[CH2:8][CH2:7][C:6](=[O:9])[C:5]=1[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([O:18]CC)=[O:17])[CH3:2].[OH-].[Na+]>C(O)C>[CH2:1]([O:3][C:4]1[CH2:8][CH2:7][C:6](=[O:9])[C:5]=1[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17])[CH3:2]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 21569671HCID 21569671, 화합물

생성물 1

HCID 21569669HCID 21569669, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture containing 22.16 parts of ethyl 2-ethoxy-5-oxocyclopent 1-eneheptanoate, 785 parts of 0.1N aqueous sodium hydroxide and 320 parts of ethanol is stored at room temperature for about 48 hours, then is concentrated to approximately 2/3 volume by distillation under reduced pressure. The residual solution is washed with ether, acidified with dilute hydrochloric acid, then extracted with ethyl acetate. The ethyl acetate extracts are washed with water, dried over anhydrous magnesium sulfate and evaporated to dryness by distillation under reduced pressure. The residual solid residue is purified by recrystallization from ether-benzene to afford 2-ethoxy-5-oxocyclopent-1-eneheptanoic acid, melting at about 65°-66°.

후처리

  1. concentrationis concentrated to approximately 2/3 volume by distillation under reduced pressure
  2. washThe residual solution is washed with ether
  3. extractionextracted with ethyl acetate
  4. washThe ethyl acetate extracts are washed with water
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customevaporated to dryness by distillation under reduced pressure
  7. customThe residual solid residue is purified by recrystallization from ether-benzene

출처 및 근거

ORD 기록
ord-200d7c0a933e44f7959e1bed07694867
출처 데이터셋
uspto-grants-1976_01
특허 번호
US03931411

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