Hydrochloric Acid → 2-Amino-6-trifluoromethylbenzyl chloride
반응식
[NH2:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]([F:13])([F:12])[F:11])[C:3]=1[CH2:4]O.[ClH:14]>>[NH2:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]([F:13])([F:12])[F:11])[C:3]=1[CH2:4][Cl:14]참가 물질
3
실험 절차
To 4.06 g (7.8 mmole) of 2-amino-6-trifluoromethylbenzyl alcohol in a pressure bottle was added 60 ml of concentrated hydrochloric acid, the bottled stoppered and immersed in an oil bath maintained at 100°. The mixture was stirred for 1.5 hr., cooled and the precipitate filtered under suction. The colorless solid was washed with water and dried under high vacuum, yielding 3.28 g (75% yield) of a colorless solid; mp 155-161°. The sample was used as such without further purification.
후처리
- customimmersed in an oil bath
- temperaturemaintained at 100°
- temperature, cooled
- filtrationthe precipitate filtered under suction
- washThe colorless solid was washed with water
- customdried under high vacuum
출처 및 근거
- ORD 기록
- ord-2ca9c4377a494b609b0d9d5114ebf55e
- 출처 데이터셋
- uspto-grants-1976_01
- 특허 번호
- US03932407
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