Potassium thiocyanate → HCID 18594805, 화합물

HRID 1580232노트

반응식

HRID 1580232 반응식
CS(O[CH:6]([CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])[CH2:7][CH2:8][C@@H:9]1[C@@H:13]([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[C:12](=[O:25])[CH2:11][CH2:10]1)(=O)=O.[S-:31][C:32]#[N:33].[K+]>CN(C)C=O>[O:25]=[C:12]1[CH2:11][CH2:10][C@H:9]([CH2:8][CH2:7][CH:6]([S:31][C:32]#[N:33])[CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])[C@H:13]1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21]

참가 물질

4

반응물 2

HCID 516872Potassium thiocyanateHCID 18594876HCID 18594876, 화합물

생성물 1

HCID 18594805HCID 18594805, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of 1 g. of ethyl 15-methanesulfonyloxy-9-oxo-prostanoate (Example 90) and 1 g. of dry potassium thiocyanate in 30 ml. of N,N-dimethylformamide is heated on the steam bath for 18 hours. The resulting mixture is poured into 150 ml. of water and extracted with ether. The extract is washed with water, dried with anhydrous magnesium sulfate and taken to dryness. Silica gel chromatography of the residue gives 462 mg. of oil; λmax. 4.67 (thiocyanate group) and 5.78 μ (carbonyl groups).

후처리

  1. additionThe resulting mixture is poured into 150 ml
  2. extractionof water and extracted with ether
  3. washThe extract is washed with water
  4. dry with materialdried with anhydrous magnesium sulfate
  5. customSilica gel chromatography of the residue gives 462 mg

출처 및 근거

ORD 기록
ord-967e96d2725844f3a86cebb166b0d01d
출처 데이터셋
uspto-grants-1976_01
특허 번호
US03932472

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