Brucine → HCID 18594875, 화합물

HRID 1580234노트

반응식

HRID 1580234 반응식
[N:1]([CH:4]([CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[CH2:5][CH2:6][C@@H:7]1[C@@H:11]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[C:10](=[O:23])[CH2:9][CH2:8]1)=[N+]=[N-].COC1C=C2[C@@]34[C@@H]5C[C@H]6C(CN5CC3)=CCO[C@H]3CC(=O)N([C@H]4[C@@H]63)C2=CC=1OC>[Pd]>[NH2:1][CH:4]([CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[CH2:5][CH2:6][C@@H:7]1[C@@H:11]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[C:10](=[O:23])[CH2:9][CH2:8]1

참가 물질

4

반응물 2

HCID 442021BrucineHCID 18594802HCID 18594802, 화합물

생성물 1

HCID 18594875HCID 18594875, 화합물

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

A 1.06 g. sample of ethyl 15-azido-9-oxo-prostanoate (Example 110) is hydrogenated using 100 mg. of 5% palladium on carbon in 50 ml. absolute alcohol for 16 hours. The filtration of the catalyst and evaporation of the solvent affords an oil. Silica gel chromatography gives 604 mg. of oil; λmax. 2.95, 6.30 (brucine) and 5.72 μ (carbonyl groups).

후처리

  1. filtrationThe filtration of the catalyst and evaporation of the solvent
  2. customaffords an oil
  3. customSilica gel chromatography gives 604 mg

출처 및 근거

ORD 기록
ord-315da0e140ce4d62a8c5c3cf22356e2d
출처 데이터셋
uspto-grants-1976_01
특허 번호
US03932472

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