Hydrochloric Acid → HCID 18594801, 화합물

HRID 1580236노트

반응식

HRID 1580236 반응식
[N:1]([CH:4]([CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[CH2:5][CH2:6][C@@H:7]1[C@@H:11]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([O:20]CC)=[O:19])[C:10](=[O:23])[CH2:9][CH2:8]1)=[N+:2]=[N-:3].CO.O.[OH-].[K+].Cl>CCOCC>[N:1]([CH:4]([CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[CH2:5][CH2:6][C@@H:7]1[C@@H:11]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([OH:20])=[O:19])[C:10](=[O:23])[CH2:9][CH2:8]1)=[N+:2]=[N-:3]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 18594802HCID 18594802, 화합물HCID 22242641Methanol--water (1/1)

생성물 1

HCID 18594801HCID 18594801, 화합물

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A suspension of 880 mg. of ethyl 15-azido-9-oxoprostanoate (Example 110) in 15 ml. of methanol-water (1:1) containing 360 mg. of potassium hydroxide is stirred at ambient temperature for 18 hours. The resulting solution is acidified with dilute hydrochloric acid and the oily layer is taken up in ether. The ether is washed with saturated sodi sodium chloride solution, dried with anhydrous magnesium sulfate and taken to dryness to give 797 mg. (98%) of an oil; λmax. 3.0-3.5 broad (acid group), 4.88 (azido group), 5.78 and 5.90 (carbonyl groups).

후처리

  1. additionA suspension of 880 mg
  2. washThe ether is washed with saturated sodi sodium chloride solution
  3. dry with materialdried with anhydrous magnesium sulfate
  4. customto give 797 mg

출처 및 근거

ORD 기록
ord-a2501d6f5b5147399d3794da20a3421d
출처 데이터셋
uspto-grants-1976_01
특허 번호
US03932472

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