Ammonia → 5-(3,4-Dibromobutyl)pyridine-2-carboxamide

HRID 1580972

반응식

HRID 1580972 반응식
[Br:1][CH:2]([CH2:14][Br:15])[CH2:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([C:11](O)=[O:12])=[N:9][CH:10]=1.S(Cl)(Cl)=O.[NH3:20]>C(Cl)(Cl)Cl>[Br:1][CH:2]([CH2:14][Br:15])[CH2:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]([NH2:20])=[O:12])=[N:9][CH:10]=1

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 24386Thionyl ChlorideHCID 2167205-(3,4-Dibromobutyl)pyridine-2-carboxylic acid

생성물 1

HCID 132718775-(3,4-Dibromobutyl)pyridine-2-carboxamide

시약·촉매·용매 1

HCID 6212Chloroform용매

반응 조건

온도
50 °C

실험 절차

20 g of 5-(3,4-dibromobutyl)picolinic acid was added to 15 ml of thionyl chloride and resulting solution was kept to warm at 50°C for one-half hour. Reaction mixture was evaporated in reduced pressure and resulting oily residue was dissolved in chloroform 100 ml. Through the solution dry ammonia gas was passed for five minutes with cooling. White precipitate was removed by filtration and washed with chloroform. Filtrate and washings are combined and evaporated in reduced pressure. Resulting solid was crystallized from benzene to give 10.2 g of the pure product as platelets.

후처리

  1. customresulting solution
  2. customReaction mixture
  3. customwas evaporated in reduced pressure
  4. customresulting oily residue
  5. temperaturewith cooling
  6. customWhite precipitate was removed by filtration
  7. washwashed with chloroform
  8. customevaporated in reduced pressure
  9. customResulting solid
  10. customwas crystallized from benzene

출처 및 근거

ORD 기록
ord-024697468ebd42488821dcb604921c7d
출처 데이터셋
uspto-grants-1976_01
특허 번호
US03935221

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