Ammonia → 5-(3,4-Dibromobutyl)pyridine-2-carboxamide

HRID 1580973

반응식

HRID 1580973 반응식
[Br:1][CH:2]([CH2:14][Br:15])[CH2:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([C:11](O)=[O:12])=[N:9][CH:10]=1.[NH3:16]>C(O)C.Cl>[Br:1][CH:2]([CH2:14][Br:15])[CH2:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]([NH2:16])=[O:12])=[N:9][CH:10]=1

참가 물질

5

반응물 2

HCID 222AmmoniaHCID 2167205-(3,4-Dibromobutyl)pyridine-2-carboxylic acid

생성물 1

HCID 132718775-(3,4-Dibromobutyl)pyridine-2-carboxamide

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 702Ethanol용매2회

실험 절차

10 g of 5-(3,4-dibromobutyl)picolinic acid was dissolved in 200 ml of ethanol saturated with dry hydrochloride gas and resulting solution was refluxed for six hours. Reaction mixture was evaporated in reduced pressure and resulting pale yellow oil was dissolved in 300 ml of ethanol saturated with dry ammonia gas. The solution was kept to stand at room temperature for three days, and then evaporated in reduced pressure. Resulting solid was crystallized from benzene to give 6.5 g of the pure product as platelets.

후처리

  1. customresulting solution
  2. temperaturewas refluxed for six hours
  3. customReaction mixture
  4. customwas evaporated in reduced pressure
  5. customresulting pale yellow oil
  6. customevaporated in reduced pressure
  7. customResulting solid
  8. customwas crystallized from benzene

출처 및 근거

ORD 기록
ord-dcd86b428b6948b8a5f064103ab4adad
출처 데이터셋
uspto-grants-1976_01
특허 번호
US03935221

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