Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1581068생성일: 2026년 10월 27일
Hydrochloric Acid → (6alpha-Fluoro-11beta-hydroxy-3,20-dioxo-16alpha-methyl-1,4-pregnadien-21-yl) hydrogen succinate
https://huagongshe.com/reaction/1581068
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Succinic anhydride | HCID 7922 | — |
| 반응물 | Fluocortolone | HCID 9053 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | (6alpha-Fluoro-11beta-hydroxy-3,20-dioxo-16alpha-methyl-1,4-pregnadien-21-yl) hydrogen succinate | HCID 68130487 | — |
반응 단계
Five grams of 6α-fluoro-11β,21 -dihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione is refluxed in 25 ml. of pyridine with 5 g. of succinic acid anhydride for 2 hours. After cooling to 20°C., the solution is stirred into ice water, acidified with hydrochloric acid, and the thus-precipitated product is vacuumfiltered, washed with water, and dried. By recrystallization from ethyl acetate, 4.85 g. of (6α-fluoro-11β-hydroxy-3,20-dioxo-16α-methyl-1,4-pregnadien-21-yl) hydrogen succinate is obtained, m.p. 212°-214° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US03935245 |
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| 출처 데이터셋 | uspto-grants-1976_01 |
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| ORD ID | ord-97e028f0c2b24c91947e7d85d40ed6f2 |
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| 출처 메모 | uspto-grants-1976_01 |
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