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HRID1581068

反应详情

EQUATION

反应方程式

HRID 1581068 的结构方程式

REACTANTS

反应物

3
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：O=C1CCC(=O)O1
HCID7922

Succinic anhydride

C4H4O3

结构：C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@]2(C)[C@H]1C(=O)CO
HCID9053

Fluocortolone

C22H29FO4

PRODUCTS

生成物

1
结构：C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@]2(C)[C@H]1C(=O)COC(=O)CCC(=O)O
HCID68130487

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：c1ccncc1
溶剂HCID1049

Pyridine

C5H5N

CONDITIONS

反应条件

温度
20 °C

PROCEDURE

实验过程

Five grams of 6α-fluoro-11β,21 -dihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione is refluxed in 25 ml. of pyridine with 5 g. of succinic acid anhydride for 2 hours. After cooling to 20°C., the solution is stirred into ice water, acidified with hydrochloric acid, and the thus-precipitated product is vacuumfiltered, washed with water, and dried. By recrystallization from ethyl acetate, 4.85 g. of (6α-fluoro-11β-hydroxy-3,20-dioxo-16α-methyl-1,4-pregnadien-21-yl) hydrogen succinate is obtained, m.p. 212°-214° C.

WORKUP

后处理

  1. washwashed with water
  2. customdried
  3. customBy recrystallization from ethyl acetate, 4.85 g