Sodium Hydroxide → 3-(4,5-Dihydro-1H-imidazol-2-yl)phenol

반응식

[OH:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5](OC)=O.S(C1C=CC(C)=CC=1)(O)(=O)=O.[NH2:23][CH2:24][CH2:25][NH2:26].[OH-].[Na+]>>[OH:1][C:2]1[CH:3]=[C:4]([C:5]2[NH:23][CH2:24][CH2:25][N:26]=2)[CH:9]=[CH:10][CH:11]=1

참가 물질

반응물 3

HCID 14798Sodium Hydroxide

HCID 88068Methyl 3-Hydroxybenzoate

HCID 2250301,2-Ethanediamine, 4-methylbenzenesulfonate (1:?)

생성물 1

HCID 162181653-(4,5-Dihydro-1H-imidazol-2-yl)phenol수율 22.3%

반응 조건

온도: 210 °C

실험 절차

A mixture of methyl 3-hydroxybenzoate (5.48 g, 36.0 mmol) and 1,2-diaminoethane monotosylate (9.85 g, 42.4 mmol) is heated at 210° C. for 7 hours. After cooling, the mixture is stirred with aqueous 2N sodium hydroxide and extracted with ethyl acetate. The precipitate which formed and is present in the aqueous layer is collected by filtration and dried in vacuo to give 1.3 g (22%) of 2-(3-hydroxyphenyl)imidazoline.