Hydrazine hydrate (1:1) → 4-(2-Methoxyphenyl)-1H-pyrazole
반응식
C[N:2](C)[CH:3]=[C:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[O:13][CH3:14])[CH:5]=O.O.[NH2:17]N>C(O)C>[CH3:14][O:13][C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=1[C:4]1[CH:3]=[N:2][NH:17][CH:5]=1참가 물질
4
실험 절차
A solution of 3-dimethylamino-2-(2-methoxyphenyl)propenal (4.68 g, 22.8 mmol) and hydrazine hydrate (6.7 ml) in ethanol (100 ml) is heated at reflux for 30 minutes. The solvent is removed in vacuo and the residue is chromatographed (silica gel, dichloromethane/ethanol 95:5) to give 2.69 g of 4-(2-methoxyphenyl)pyrazole (68%).
후처리
- temperatureat reflux for 30 minutes
- customThe solvent is removed in vacuo
- customthe residue is chromatographed (silica gel, dichloromethane/ethanol 95:5)
출처 및 근거
- ORD 기록
- ord-5eed3c7b1660419eb4b7d03afb07a3e3
- 출처 데이터셋
- uspto-grants-2004_05
- 특허 번호
- US06730792B2
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