Hydrochloric Acid → Ethyl 2,4-dimethoxy-benzimidate hydrochloride

HRID 1582461

반응식

HRID 1582461 반응식
[ClH:1].[CH3:2][O:3][C:4]1[CH:11]=[C:10]([O:12][CH3:13])[CH:9]=[CH:8][C:5]=1[C:6]#[N:7].[CH2:14]([OH:16])[CH3:15]>>[ClH:1].[CH3:2][O:3][C:4]1[CH:11]=[C:10]([O:12][CH3:13])[CH:9]=[CH:8][C:5]=1[C:6](=[NH:7])[O:16][CH2:14][CH3:15]

참가 물질

4

반응물 3

HCID 313Hydrochloric Acid2회HCID 702EthanolHCID 777502,4-Dimethoxybenzonitrile

생성물 1

HCID 22721088Ethyl 2,4-dimethoxy-benzimidate hydrochloride수율 57%

실험 절차

Hydrogen chloride gas was passed through a solution of 2,4-dimethoxy-benzonitrile (5.20 g, 32 mmol) in anhydrous ethanol (200 mL) at 0° C. After 7 h, hydrogen chloride gas was stopped and the reaction mixture was stirred at room temperature overnight. The solvent was removed and the residue was triturated in diethyl ether to afford ethyl 2,4-dimethoxy-benzimidate hydrochloride (4.5 g, 57%). It was used without further purification.

후처리

  1. customThe solvent was removed
  2. customthe residue was triturated in diethyl ether

출처 및 근거

ORD 기록
ord-8df2d3d2fdad44ba9f89268a3002e98f
출처 데이터셋
uspto-grants-2004_05
특허 번호
US06734302B2

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