Ethanol → 5-Nitro-1-tetralone oxime

HRID 1582781

반응식

HRID 1582781 반응식
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH2:6][CH2:7][CH2:8][C:9]2=O)([O-:3])=[O:2].C(O)C.Cl.[NH2:19][OH:20]>O>[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH2:6][CH2:7][CH2:8][C:9]2=[N:19][OH:20])([O-:3])=[O:2]

참가 물질

5

반응물 3

HCID 702EthanolHCID 443297Hydroxyamine hydrochlorideHCID 102619465-Nitro-3,4-dihydronaphthalen-1(2H)-one

생성물 1

HCID 729651715-Nitro-1-tetralone oxime수율 90.3%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

In a 100 mL flask equipped with a reflux condenser were placed 2.26 g of 5-nitro-1-tetralone and 60 mL of ethanol. To the mixture was added a solution of hydroxylamine hydrochloride (1.82 g) in water (4.5 mL). The content of the flask was stirred with a stirring bar at reflux for 8 hours. After evaporating the solvent, the residue was purified by column chromatography (eluent: hexane/ethyl acetate=5/1)′ to give 2.2 g of 5-nitro-1-tetralone oxime.

후처리

  1. customIn a 100 mL flask equipped with a reflux condenser
  2. temperatureat reflux for 8 hours
  3. customAfter evaporating the solvent
  4. customthe residue was purified by column chromatography (eluent: hexane/ethyl acetate=5/1)′

출처 및 근거

ORD 기록
ord-8b6e3766710e4df5bfa902d7d9ed712c
출처 데이터셋
uspto-grants-2004_05
특허 번호
US06737548B2

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