Anthranilic Acid → N-Methylanthranilic acid

HRID 1583248

반응식

HRID 1583248 반응식
[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH2:11]=O.[H][H]>C(O)C.[Pt]=O>[CH3:11][NH:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

참가 물질

6

반응물 3

HCID 227Anthranilic AcidHCID 712FormaldehydeHCID 178418361HCID 178418361, 화합물2회

생성물 1

HCID 67069N-Methylanthranilic acid

시약·촉매·용매 2

HCID 82844Platinum oxide (PtO)촉매HCID 702Ethanol용매

실험 절차

A solution of 2-aminobenzoic acid (25 g) in ethanol (300 ml) reacted with an excess of paraformaldehyde and then reduced with hydrogen gas at 60 psi over platinum oxide (25 g) catalyst. After hydrogen uptake ceased, the mixture was filtered and the solvent removed on a rotary evaporator. The product was purified by chromatography on silica gel and the structure confirmed by nmr and infrared analysis.

후처리

  1. filtrationthe mixture was filtered
  2. customthe solvent removed on a rotary evaporator
  3. customThe product was purified by chromatography on silica gel

출처 및 근거

ORD 기록
ord-ed246f2e1c7046a1a8e4929d902ad398
출처 데이터셋
uspto-grants-1985_11
특허 번호
US04551279

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