Methanol → methyl 6-methyl-1H-indole-2-carboxylate

HRID 1583366노트

반응식

HRID 1583366 반응식
[CH3:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[C:7]([C:11]([OH:13])=[O:12])[NH:8]2)=[CH:4][CH:3]=1.P(Cl)(Cl)(Cl)=O.[CH3:19]O>>[CH3:19][O:12][C:11]([C:7]1[NH:8][C:9]2[C:5]([CH:6]=1)=[CH:4][CH:3]=[C:2]([CH3:1])[CH:10]=2)=[O:13]

참가 물질

4

반응물 3

HCID 887MethanolHCID 24813Phosphorus oxychlorideHCID 31633966-Methyl-1H-indole-2-carboxylic acid

생성물 1

HCID 4715128methyl 6-methyl-1H-indole-2-carboxylate

실험 절차

A solution of 6-methylindole-2-carboxylic acid (38.2 g.) in methanol (400 ml.) containing phosphorus oxychloride (5 ml.) was heated under reflux for 4 hours and then evaporated. The residue was dissolved in chloroform and the solution was washed successively with water and sodium bicarbonate solution and then dried (Na2SO4). Evaporation of the solvent gave a solid which was crystallized from methanol to give 6-methylindole-2-carboxylic acid methyl ester (28.1 g.), m.p. 128°-131° C.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 4 hours
  3. customevaporated
  4. dissolutionThe residue was dissolved in chloroform
  5. washthe solution was washed successively with water and sodium bicarbonate solution
  6. dry with materialdried (Na2SO4)
  7. customEvaporation of the solvent
  8. customgave a solid which
  9. customwas crystallized from methanol

출처 및 근거

ORD 기록
ord-d885f50433e44c1e87296268805ce8f0
출처 데이터셋
uspto-grants-1985_11
특허 번호
US04551468

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