Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Hydroxybenzaldehyde → 4-(2-Fluoroethoxy)benzaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Hydroxybenzaldehyde | HCID 126 | — |
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1-Chloro-2-fluoroethane | HCID 12983 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-(2-Fluoroethoxy)benzaldehyde | HCID 15058649 | 99.4% |
반응 단계
4-Hydroxybenzaldehyde (26.0 g), 20.7 g of 1-fluoro-2-chloroethane and 42.4 g of anhydrous potassium carbonate were added to 100 ml of dimethylformamide, and reacted at 130° C. for 5 hours. After the reaction, the reaction mixture was cooled to room temperature, poured into water, and then extracted with toluene. The toluene layer was washed with water, and dried over anhydrous sodium sulfate. Toluene was evaporated under reduced pressure to give 35.6 g of crude 4-(2-fluoroethoxy)benzaldehyde.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04552894 |
| 출처 데이터셋 | uspto-grants-1985_11 |
| ORD ID | ord-b5bd587e41f9426ca54f2eeb795b3b09 |
| 출처 메모 | uspto-grants-1985_11 |