反应详情

4-Hydroxybenzaldehyde (26.0 g), 20.7 g of 1-fluoro-2-chloroethane and 42.4 g of anhydrous potassium carbonate were added to 100 ml of dimethylformamide, and reacted at 130° C. for 5 hours. After the reaction, the reaction mixture was cooled to room temperature, poured into water, and then extracted with toluene. The toluene layer was washed with water, and dried over anhydrous sodium sulfate. Toluene was evaporated under reduced pressure to give 35.6 g of crude 4-(2-fluoroethoxy)benzaldehyde.

1. customreacted at 130° C. for 5 hours
2. customAfter the reaction
3. extractionextracted with toluene
4. washThe toluene layer was washed with water
5. dry with materialdried over anhydrous sodium sulfate
6. customToluene was evaporated under reduced pressure