Water → (4-(2-Fluoroethoxy)phenyl)methanol

HRID 1583582노트

반응식

HRID 1583582 반응식
[F:1][CH2:2][CH2:3][O:4][C:5]1[CH:12]=[CH:11][C:8]([CH:9]=[O:10])=[CH:7][CH:6]=1.[BH4-].[Na+].O>C(O)C>[F:1][CH2:2][CH2:3][O:4][C:5]1[CH:12]=[CH:11][C:8]([CH2:9][OH:10])=[CH:7][CH:6]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 4311764Sodium borohydride2회HCID 150586494-(2-Fluoroethoxy)benzaldehyde

생성물 1

HCID 13367643(4-(2-Fluoroethoxy)phenyl)methanol수율 89.9%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

The crude 4-(2-fluoroethoxy)benzaldehyde (35.6 g) was dissolved in 140 ml of ethanol, and 11.0 g of sodium borohydride was carefully added to the solution at 47° to 50° C. After adding sodium borohydride, the reaction was carried out at 50° C. for 2 hours. After the reaction, the reaction mixture was cooled to room temperature and water was added. The mixture was extracted with toluene. The toluene layer was washed with water and dried over anhydrous sodium sulfate. Toluene was evaporated under reduced pressure to give 32.4 g of 4-(2-fluoroethoxy)benzyl alcohol as crystals (m.p. 37.3°-38.0° C.).

후처리

  1. customAfter the reaction
  2. extractionThe mixture was extracted with toluene
  3. washThe toluene layer was washed with water
  4. dry with materialdried over anhydrous sodium sulfate
  5. customToluene was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-346c693605af4bd19f5fe687b931aa98
출처 데이터셋
uspto-grants-1985_11
특허 번호
US04552894

반응 노트

불러오는 중…