Dimethylformamide → 4-(2-Fluoroethoxy)isopropenylbenzene

HRID 1583585

반응식

HRID 1583585 반응식
CN(C)C=O.[C:6]([C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=1)([CH3:8])=[CH2:7].[F:16][CH2:17][CH2:18]Cl.C(=O)([O-])[O-].[K+].[K+]>O>[F:16][CH2:17][CH2:18][O:15][C:12]1[CH:13]=[CH:14][C:9]([C:6]([CH3:8])=[CH2:7])=[CH:10][CH:11]=1

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 129831-Chloro-2-fluoroethaneHCID 584247p-Isopropenylphenol

생성물 1

HCID 202592654-(2-Fluoroethoxy)isopropenylbenzene수율 95.7%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To 30 ml of dimethylformamide were added 7.0 g of 4-isopropenylphenol, 6.1 g of 1-fluoro-2-chloroethane and 8.7 g of potassium carbonate. With stirring, they were reacted at 120° C. for 4 hours. The reaction mixture was cooled to room temperature, and poured into water. The mixture was then extracted with toluene. The toluene layer was washed with water and dried over anhydrous sodium sulfate. Toluene was evaporated under reduced pressure to give 9.0 g of crude 4-(2-fluoroethoxy)isopropenylbenzene.

후처리

  1. customthey were reacted at 120° C. for 4 hours
  2. extractionThe mixture was then extracted with toluene
  3. washThe toluene layer was washed with water
  4. dry with materialdried over anhydrous sodium sulfate
  5. customToluene was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-c8440b73d64141fe9a53354cfa7b5462
출처 데이터셋
uspto-grants-1985_11
특허 번호
US04552894

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