N-((Phenylmethoxy)carbonyl)-L-alanyl-L-alanine → HCID 13750000, 화합물

HRID 1583724

반응식

HRID 1583724 반응식
[CH2:1]([O:8][C:9]([NH:11][C@H:12]([C:14]([NH:16][C@H:17]([C:19]([OH:21])=O)[CH3:18])=[O:15])[CH3:13])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:22]([NH2:24])[CH3:23].[NH:25]1[CH2:32][CH2:31][CH2:30][C@H:26]1[C:27](O)=[O:28]>CN(C)C=O>[CH2:22]([NH:24][C:27](=[O:28])[C@@H:26]1[CH2:30][CH2:31][CH2:32][N:25]1[C:19](=[O:21])[C@H:17]([CH3:18])[NH:16][C:14](=[O:15])[C@H:12]([CH3:13])[NH:11][C:9]([O:8][CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)=[O:10])[CH3:23]

참가 물질

4

반응물 2

HCID 7009583N-((Phenylmethoxy)carbonyl)-L-alanyl-L-alanineHCID 70479868HCID 70479868, 화합물

생성물 1

HCID 13750000HCID 13750000, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매2회

반응 조건

온도
-5 °C

실험 절차

11 grams of N,N-dicyclohexylcarbodiimide was added to a solution of 14.7 grams of benzyloxycarbonylalanyl alanine in 100 ml of dimethylformamide and 7.6 g of proline ethylamine (prepared from the corresponding benzyloxycarbonyl derivative) cooled to -5 degrees C. and the reaction mixture treated by conventional techniques. 10.6 g of product having a melting point of 139 to 140 degrees C. was obtained. [α]D20 -46.5 degrees (c 0.3; dimethylformamide).

후처리

  1. additionand the reaction mixture treated by conventional techniques
  2. customwas obtained

출처 및 근거

ORD 기록
ord-d31229fcf48e40f89b133e52964b1a19
출처 데이터셋
uspto-grants-1985_11
특허 번호
US04554100

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