L-Aspartic Acid → N-acetoacetylaspartic acid

HRID 1583890

반응식

COC(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@H](CC(=O)O)N.[NH2:22][C@H:23]([C:28]([OH:30])=[O:29])[CH2:24][C:25]([OH:27])=[O:26].[CH2:31]=[C:32]1[O:36][C:34](=[O:35])[CH2:33]1>>[C:34]([NH:22][C@H:23]([C:28]([OH:30])=[O:29])[CH2:24][C:25]([OH:27])=[O:26])(=[O:35])[CH2:33][C:32]([CH3:31])=[O:36]

참가 물질

반응물 3

HCID 5960L-Aspartic Acid

HCID 12661Diketene

HCID 134601Aspartame

생성물 1

HCID 13334672N-acetoacetylaspartic acid

실험 절차

This invention encompasses a method and intermediates for preparing a commercial sweetening agent, α-L-aspartyl-L-phenylalanine methyl ester. The process involves reacting L-aspartic acid with diketene to form N-acetoacetyl-L-aspartic acid which is converted to N-acetoacetyl-L-aspartic anhydride by reaction with acetic anhydride. N-acetoacetyl-L-aspartic anhydride is reacted with L-phenylalanine methyl ester to provide N-acetoacetyl-α-L-aspartyl-L-phenylalanine methyl ester which is converted to α-L-aspartyl-L-phenylalanine methyl ester by reaction with hydroxylamine hydrochloride.

출처 및 근거

ORD 기록: ord-ab494669b5ee4a88b6e906dff1bbd8c0
출처 데이터셋: uspto-grants-1985_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04555362

연결된 노트

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