Methylhydrazine → 3(2H)-Pyridazinone, 6-(4-chlorophenyl)-4,5-dihydro-2-methyl-
반응식
[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([C:6]([CH2:8][CH2:9][C:10](O)=[O:11])=O)=[CH:4][CH:3]=1.[CH3:15][NH:16][NH2:17]>C(O)C>[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([C:6]2[CH2:8][CH2:9][C:10](=[O:11])[N:16]([CH3:15])[N:17]=2)=[CH:4][CH:3]=1참가 물질
4
실험 절차
To a 250 ml flask equipped with magnetic stirrer and reflux condenser was charged 10 g of 3-(4-chlorobenzoyl)-propionic acid, 250 ml. of absolute ethanol, and 2.5 ml of methyl hydrazine. The reaction was refluxed for 3 hours and cooled to yield a solid which was collected by vacuum filtration, washed with 50 ml of hexane, and air dried. Isolated 9.5 g of product as a white solid.
후처리
- customTo a 250 ml flask equipped with magnetic stirrer
- temperaturereflux condenser
- temperatureThe reaction was refluxed for 3 hours
- temperaturecooled
- customto yield a solid which
- filtrationwas collected by vacuum filtration
- washwashed with 50 ml of hexane, and air
- customdried
출처 및 근거
- ORD 기록
- ord-b13d649eb0e543419a54c9aec5175c91
- 출처 데이터셋
- uspto-grants-1998_03
- 특허 번호
- US05726176
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