Thiazolidinedione → 4-Chloro-2-oxo-2,3-dihydro-1,3-thiazole-5-carbaldehyde

HRID 1584024노트

반응식

HRID 1584024 반응식
[S:1]1[CH2:5][C:4](=O)[NH:3][C:2]1=[O:7].P(Cl)(Cl)([Cl:10])=O.CN(C)[CH:15]=[O:16]>>[Cl:10][C:4]1[NH:3][C:2](=[O:7])[S:1][C:5]=1[CH:15]=[O:16]

참가 물질

4

반응물 3

HCID 5437ThiazolidinedioneHCID 6228DimethylformamideHCID 24813Phosphorus oxychloride

생성물 1

HCID 121980294-Chloro-2-oxo-2,3-dihydro-1,3-thiazole-5-carbaldehyde수율 40%

반응 조건

온도
80 °C

실험 절차

The reaction between 2,4-thiazolidinedione (III), dimethylformamide and phosphorus oxychloride is described in Khim. Geterotsikl. Soedin 1975, page 85 (English translation: Chem. Het. Comp. 1975, page 73). In this reaction, the three substances mentioned are, in an optimum molar ratio of 1:1.5:3, heated at 80° C. for 16 hours and at 115° to 130° C. for a short time and then hydrolyzed, whereupon 4-chloro-2,3-dihydro-2-oxo-5-thiazolecarboxaldehyde of the formula (I) ##STR2## is obtained in 40 to 60% yield.

후처리

  1. customIn this reaction

출처 및 근거

ORD 기록
ord-6e7d502e616449cebea8842f82602338
출처 데이터셋
uspto-grants-1985_11
특허 번호
US04555577

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