Hydrochloric Acid → 1,2,3,4-Tetrahydro-isoquinoline-3(S)-carboxylic acid {2-[3-(4-cyanobenzyl)-3H-imidazol-4-yl]-ethyl}-amide hydrochloride

HRID 1584269노트

반응식

HRID 1584269 반응식
[C:1]([C:3]1[CH:36]=[CH:35][C:6]([CH2:7][N:8]2[C:12]([CH2:13][CH2:14][NH:15][C:16]([C@@H:18]3[CH2:27][C:26]4[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=4)[CH2:20][N:19]3C(OC(C)(C)C)=O)=[O:17])=[CH:11][N:10]=[CH:9]2)=[CH:5][CH:4]=1)#[N:2].[ClH:37]>CCOC(C)=O>[ClH:37].[C:1]([C:3]1[CH:4]=[CH:5][C:6]([CH2:7][N:8]2[C:12]([CH2:13][CH2:14][NH:15][C:16]([C@@H:18]3[CH2:27][C:26]4[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=4)[CH2:20][NH:19]3)=[O:17])=[CH:11][N:10]=[CH:9]2)=[CH:35][CH:36]=1)#[N:2]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 701032202-(t-Butyloxycarbonyl)-1,2,3,4-tetrahydro-isoquinoline-3(S)-carboxylic acid {2-[3-(4-cyanobenzyl)-3H-imidazol-4-yl]-ethyl}-amide

생성물 1

HCID 701220621,2,3,4-Tetrahydro-isoquinoline-3(S)-carboxylic acid {2-[3-(4-cyanobenzyl)-3H-imidazol-4-yl]-ethyl}-amide hydrochloride

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

반응 조건

온도
25 °C

실험 절차

A solution of 2-(t-butyloxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3(S)-carboxylic acid {2-[3-(4-cyanobenzyl)-3H-imidazol-4-yl]-ethyl}-amide (0.25 g, 0.52 mmol) in EtOAc (15 mL) was cooled to -20° C. The solution was saturated with HCl gas and stirred at 0° C. for 0.5 hr and 25° C. for an additional 0.5 hr. The reaction was evaporated in vacuo to obtain the title compound which was used without further purification.

후처리

  1. customThe reaction was evaporated in vacuo

출처 및 근거

ORD 기록
ord-3499189afff04f018e0f1f99021e9a43
출처 데이터셋
uspto-grants-1999_08
특허 번호
US05932590

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