Acetic Anhydride → Erythromycin 2'-acetate

HRID 1584542

반응식

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참가 물질

반응물 3

HCID 7918Acetic Anhydride

HCID 8857Ethyl Acetate

HCID 9918244Erythromycin B

생성물 1

HCID 114919Erythromycin 2'-acetate

실험 절차

Into a 1.0 L one neck round bottom flask were placed 50 g of erythromycin B (69.64 m mole), 500 mL ethyl acetate and 16 mL acetic anhydride (17.3 g, 169.6 m mole). The solution was stirred at room temperature overnight. Copious amounts of white solids were observed. This mixture was filtered to give 26.2 g solid. The filtrate was washed with 300 mL 5% sodium bicarbonate twice, and the organic layer was dried with magnesium sulfate. The solvent was removed by vacuum distillation to give a second crop of desired product (22.3 g). The product was identified by mass spectroscopy and NMR.

후처리

filtrationThis mixture was filtered

출처 및 근거

ORD 기록: ord-12588214e2ce44aca836d711cda4f78a
출처 데이터셋: uspto-grants-1999_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05932710

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