Acetonitrile → HCID 70133040, 화합물

HRID 1584669노트

반응식

HRID 1584669 반응식
C(O[C:9](=[O:26])[CH2:10][N:11]([CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)C1C=CC=CC=1.[C:27](#[N:29])[CH3:28].[NH2-].[Na+].[CH2:32]([Mg]Cl)[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1>CC(OC)(C)C>[NH2:29][C:27]([CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)=[CH:28][C:9](=[O:26])[CH2:10][N:11]([CH2:12][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)[CH2:19][C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

참가 물질

6

반응물 4

HCID 6342AcetonitrileHCID 24533Sodium amideHCID 4683020Glycine, N,N-bis(phenylMethyl)-, phenylMethyl esterHCID 178418336HCID 178418336, 화합물

생성물 1

HCID 70133040HCID 70133040, 화합물

시약·촉매·용매 1

HCID 15413tert-Butyl methyl ether용매

실험 절차

The title compound was prepared from N,N-dibenzyl-glycine benzyl ester, 54 mmole, and 3.3 mL, 64 mmole of acetonitrile. Following the procedure described in Example 2 the ester and nitrile mixture was added to 5.5 g, 127 mmole of sodium amide in MTBE. After solvent removal, benzyl magnesium chloride (PhCH2MgCl 145 mmole) was added following the procedure in Example 2. The resulting enamine was purified by chromatography, following the procedure described in Example 4. The yield of enamine was 22.3 g (50 mmole, 78%).

후처리

  1. additionwas added
  2. customThe resulting enamine was purified by chromatography

출처 및 근거

ORD 기록
ord-e1a3f166e29044b39a9dbf6ecb2f6839
출처 데이터셋
uspto-grants-1999_08
특허 번호
US05932766

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