Water → HCID 21220308, 화합물

HRID 1584816노트

반응식

HRID 1584816 반응식
[Br:1][C:2]1[C:20]([F:21])=[CH:19][C:5]([C:6]([C:8](=[CH:14][NH:15][CH:16]2[CH2:18][CH2:17]2)[C:9]([O:11][CH2:12][CH3:13])=[O:10])=[O:7])=[C:4](F)[C:3]=1[CH3:23].C(=O)([O-])[O-].[K+].[K+].O>CS(C)=O>[Br:1][C:2]1[C:3]([CH3:23])=[C:4]2[C:5]([C:6](=[O:7])[C:8]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:14][N:15]2[CH:16]2[CH2:18][CH2:17]2)=[CH:19][C:20]=1[F:21]

참가 물질

5

반응물 3

HCID 962WaterHCID 11430Potassium CarbonateHCID 178471861HCID 178471861, 화합물

생성물 1

HCID 21220308HCID 21220308, 화합물

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

반응 조건

온도
100 °C

실험 절차

In 175 ml of dimethyl sulfoxide was dissolved 35.0 g of ethyl 2-(4-bromo-2,5-difluoro-3-methylbenzoyl)-3-cyclopropylaminoacrylate, and 27.4 g of potassium carbonate was added to the solution, after which the resulting mixture was stirred at 100° C. for 30 minutes. The reaction mixture was cooled to room temperature, and 1,000 ml of water was then added thereto, after which the crystals formed were collected by filtration, to obtain 30.0 g of colorless, crystalline ethyl 7-bromo-1-cyclopropyl-6-fluoro-8-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylate.

후처리

  1. additionwas added to the solution
  2. temperatureThe reaction mixture was cooled to room temperature
  3. customafter which the crystals formed
  4. filtrationwere collected by filtration

출처 및 근거

ORD 기록
ord-ff799f89d2c648c1a90fc65a51119b63
출처 데이터셋
uspto-grants-1999_08
특허 번호
US05935952

반응 노트

불러오는 중…