Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonium Chloride → 5-(Hydroxymethyl)furan-2-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 반응물 | Methyl 5-cyanofuran-2-carboxylate | HCID 13011707 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 5-(Hydroxymethyl)furan-2-carbonitrile | HCID 3021406 | — |
반응 단계
A solution of the ester from step 1 (0.098 g, 0.652 mmol), in ethanol (2.5 ml) at 0° C. was treated with sodium borohydride (0.11 g, 2.936 mmol) and the reaction was stirred for 2 hrs. Saturated NH4Cl solution (1 ml) was added and the aqueous extracted with diethylether. The combined extracts were dried (MgSO4) and evaporated in vacuo. The residue was chromatographed (silica gel, diethylether) to afford the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05939439 |
| 출처 데이터셋 | uspto-grants-1999_08 |
| ORD ID | ord-92585bef1193432a95ed990f1dd1fe62 |
| 출처 메모 | uspto-grants-1999_08 |