3-Nitrophenylethyl alcohol → 2-(3-Aminophenyl)ethan-1-ol

HRID 15859

반응식

HRID 15859 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][CH2:11][OH:12])[CH:7]=[CH:8][CH:9]=1)([O-])=O.C([O-])=O.[NH4+]>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([CH2:10][CH2:11][OH:12])[CH:7]=[CH:8][CH:9]=1

참가 물질

5

반응물 2

HCID 1040583-Nitrophenylethyl alcoholHCID 2723923Ammonium formate

생성물 1

HCID 149389872-(3-Aminophenyl)ethan-1-ol수율 54%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

2-(3-Nitrophenyl)ethanol (836 mg, 5.00 mmol) and Pd (10% on charcoal, 200 mg) were suspended in dry methanol (10 mL). After the addition of ammonium formate (1.450 g, 23 mmol) a slightly exothermic and effervescent reaction was observed. After stirring for 1 h at room temperature the mixture was filtered over celite. The filtrate was evaporated and the residue dissolved in ethyl acetate. After washing with saturated aqueous sodium hydrogencarboante solution, water and brine the organic layer was dried (magnesium sulfate) and the solvent removed under reduced pressure affording the title compound in 54% yield (373 mg) as a white solid.

후처리

  1. customeffervescent reaction
  2. filtrationwas filtered over celite
  3. customThe filtrate was evaporated
  4. dissolutionthe residue dissolved in ethyl acetate
  5. washAfter washing with saturated aqueous sodium hydrogencarboante solution, water and brine the organic layer
  6. dry with materialwas dried (magnesium sulfate)
  7. customthe solvent removed under reduced pressure

출처 및 근거

ORD 기록
ord-824ab447f90a413daf02962ad5f273a6
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07732600B2

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