N-Iodosuccinimide → HCID 178478182, 화합물

HRID 1586358노트

반응식

HRID 1586358 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:13]=[CH:12][NH:11][N:10]=2)[CH:5]=[C:6]([Cl:8])[CH:7]=1.C1C(=O)N([I:21])C(=O)C1>ClCCl>[I:21][C:13]1[C:9]([C:4]2[CH:3]=[C:2]([Cl:1])[CH:7]=[C:6]([Cl:8])[CH:5]=2)=[N:10][NH:11][CH:12]=1

참가 물질

4

반응물 2

HCID 120273N-IodosuccinimideHCID 178478180HCID 178478180, 화합물

생성물 1

HCID 178478182HCID 178478182, 화합물수율 59%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

2.13 g (0.01 mol) of 3-(3,5-dichlorophenyl)pyrazole are dissolved, at room temperature and with stirring, in 50 ml of dichloromethane. 2.5 g (0.011 mol) of n-iodosuccinimide are then added and stirring is then continued for 4 days. The reaction mixture is then concentrated, the solid obtained is washed with heptane and boiled in 100 ml of 1N sodium hydroxide. After cooling, the solid is filtered, washed with water and dried to give 2 g (yield 59%, melting point: 170° C.) of 4-iodo-3-(3,5-dichlorophenyl)pyrazole.

후처리

  1. concentrationThe reaction mixture is then concentrated
  2. customthe solid obtained
  3. washis washed with heptane
  4. temperatureAfter cooling
  5. filtrationthe solid is filtered
  6. washwashed with water
  7. customdried

출처 및 근거

ORD 기록
ord-a6e693548f194d1cb81482a444275690
출처 데이터셋
uspto-grants-1999_08
특허 번호
US05945382

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