Hydrochloric Acid → (2S)-piperazine-2-carboxylic acid dihydrochloride

HRID 1586536노트

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HRID 1586536 반응식
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][C@H:2]1[C:7]([O:9]C(C)(C)C)=[O:8].[ClH:14]>O>[ClH:14].[ClH:14].[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][C@H:2]1[C:7]([OH:9])=[O:8]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 45115680HCID 45115680, 화합물

생성물 1

HCID 2734260(2S)-piperazine-2-carboxylic acid dihydrochloride

시약·촉매·용매 1

HCID 962Water용매

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온도
0 °C

실험 절차

The crude tert-butyl (S)-piperazine-2-carboxylate from Example 7 was stirred in 2.9 g of water and 2.1 g (18.4 mmol) of 32 percent hydrochloric acid for 20 minutes at 100° C. The mixture was cooled to 0° C. and stirred for a further 1 hour. The hydrochloride which had precipitated out was filtered off and washed with 10 ml of dichloromethane. The yield of the title compound was 0.24 g (41 percent, based on tert-butyl pyrazinecarboxylate). The ee value was 77.6 percent.

후처리

  1. customThe hydrochloride which had precipitated out
  2. filtrationwas filtered off
  3. washwashed with 10 ml of dichloromethane

출처 및 근거

ORD 기록
ord-0ee039259ffc44829d7a2b491a05c2bb
출처 데이터셋
uspto-grants-1999_08
특허 번호
US05945534

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