Sodium borohydride → 4-Amino-6,6'-dimethyl-2,2'-bipyridine

HRID 1586928노트

반응식

HRID 1586928 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([N+:16]([O-])=O)[CH:5]=[C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH3:15])[N:10]=2)[N+:7]=1[O-].[BH4-].[Na+]>CO.[Pd]>[NH2:16][C:4]1[CH:3]=[C:2]([CH3:1])[N:7]=[C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH3:15])[N:10]=2)[CH:5]=1

참가 물질

5

반응물 2

HCID 4311764Sodium borohydrideHCID 110321326,6'-Dimethyl-4-nitro-2,2'-bipyridine-N-oxide

생성물 1

HCID 197601464-Amino-6,6'-dimethyl-2,2'-bipyridine수율 80%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

6,6'-Dimethyl-4-nitro-2,2'-bipyridine-N-oxide (17) (2.0 g, 8.2 mmoles) was dissolved in methanol (20 ml). 10% palladium on carbon (0.36 g) was added followed by slow addition of sodium borohydride (3.6 g, 95 mmoles). After one hour the reaction mixture was filtered and the solution was evaporated. The residue was dissolved in 0.1N sodium hydroxide solution and the product was extracted with chloroform from the water phase. The chloroform phase was dried and evaporated. Yield: 80%

후처리

  1. filtrationAfter one hour the reaction mixture was filtered
  2. customthe solution was evaporated
  3. dissolutionThe residue was dissolved in 0.1N sodium hydroxide solution
  4. extractionthe product was extracted with chloroform from the water phase
  5. dry with materialThe chloroform phase was dried
  6. customevaporated

출처 및 근거

ORD 기록
ord-4d57c6ee2b8449659bd38058f53038b3
출처 데이터셋
uspto-grants-1993_06
특허 번호
US05216134

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