Sodium borohydride → 4-(2-Hydroxyethoxy)-6,6'-dimethyl-2,2'-bipyridine
반응식
[OH:1][CH2:2][CH2:3][O:4][C:5]1[CH:6]=[C:7]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([CH3:19])[N:14]=2)[N+:8]([O-])=[C:9]([CH3:11])[CH:10]=1.[BH4-].[Na+]>CO.[Pd]>[OH:1][CH2:2][CH2:3][O:4][C:5]1[CH:10]=[C:9]([CH3:11])[N:8]=[C:7]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([CH3:19])[N:14]=2)[CH:6]=1참가 물질
5
실험 절차
4-(2-hydroxyethoxy)-6,6'-dimethyl-2,2'-bipyridine-N-oxide (23) (2.40 g, 9.22 mmoles) was dissolved in methanol (75 ml). 10% palladium on carbon (0.54 g) was added and then slowly sodium borohydride (3.24 g, 85.6 mmoles). Palladium on carbon was filtered out and the solvent was evaporated. The product was purified by means of flash chromatography (silica, 5-50% methanol/chloroform).
후처리
- filtrationPalladium on carbon was filtered out
- customthe solvent was evaporated
- customThe product was purified by means of flash chromatography (silica, 5-50% methanol/chloroform)
출처 및 근거
- ORD 기록
- ord-50da65f52c124b6ea43302440c8aaecf
- 출처 데이터셋
- uspto-grants-1993_06
- 특허 번호
- US05216134
반응 노트
불러오는 중…