Tributylstannane → (E)-3-(tributylstannyl)prop-2-en-1-ol

HRID 1587015노트

반응식

HRID 1587015 반응식
[CH2:1]([OH:4])[C:2]#[CH:3].[CH2:5]([SnH:9]([CH2:14][CH2:15][CH2:16][CH3:17])[CH2:10][CH2:11][CH2:12][CH3:13])[CH2:6][CH2:7][CH3:8]>C1(C)C=CC=CC=1>[CH2:14]([Sn:9]([CH2:5][CH2:6][CH2:7][CH3:8])([CH2:10][CH2:11][CH2:12][CH3:13])/[CH:3]=[CH:2]/[CH2:1][OH:4])[CH2:15][CH2:16][CH3:17]

참가 물질

4

반응물 2

HCID 5948TributylstannaneHCID 7859Propargyl alcohol

생성물 1

HCID 10043273(E)-3-(tributylstannyl)prop-2-en-1-ol

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a mixture of propargyl alcohol (2.24 g) and α,α'-azoisobutyronitrile (0.10 g) in anhydrous toluene (150 ml) is added tributyltin hydride (12.9 ml) and the mixture heated at reflux for about 2.5 hours, cooled and concentrated in vacuo. The crude product is purified by flash chromatography in 15% ether in hexane to give the desired product.

후처리

  1. temperaturethe mixture heated
  2. temperatureat reflux for about 2.5 hours
  3. temperaturecooled
  4. concentrationconcentrated in vacuo
  5. customThe crude product is purified by flash chromatography in 15% ether in hexane

출처 및 근거

ORD 기록
ord-96f7297063ff4536a13820f86abb994a
출처 데이터셋
uspto-grants-1993_06
특허 번호
US05216015

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