Water → HCID 18652192, 화합물

HRID 1587035노트

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HRID 1587035 반응식
[C:1]([O:4][C@@H:5]1[CH2:26][CH2:25][C@@:24]2([CH3:27])[C@H:7]([CH2:8][CH2:9][C:10]3[C@@H:23]2[CH2:22][C@H:21]([O:28][C:29](=[O:35])[C:30]([CH3:34])([CH3:33])[CH2:31][CH3:32])[C@@:20]2([CH3:36])[C:11]=3[CH2:12][CH2:13][C@@H:14]2[C@H:15]([CH3:19])[CH2:16][CH:17]=[CH2:18])[CH2:6]1)(=[O:3])[CH3:2].C(O)(C)(C)C.[OH2:42].[OH2:43].C[N+]1([O-])CCOCC1>C(OCC)(=O)C.CCOCC.[Os](=O)(=O)(=O)=O>[C:1]([O:4][C@@H:5]1[CH2:26][CH2:25][C@@:24]2([CH3:27])[C@H:7]([CH2:8][CH2:9][C:10]3[C@@H:23]2[CH2:22][C@H:21]([O:28][C:29](=[O:35])[C:30]([CH3:34])([CH3:33])[CH2:31][CH3:32])[C@@:20]2([CH3:36])[C:11]=3[CH2:12][CH2:13][C@@H:14]2[C@H:15]([CH3:19])[CH2:16][CH:17]([OH:43])[CH2:18][OH:42])[CH2:6]1)(=[O:3])[CH3:2]

참가 물질

8

반응물 4

HCID 962WaterHCID 6386tert-ButanolHCID 2724197N-Methylmorpholine N-oxide monohydrateHCID 67857040HCID 67857040, 화합물

생성물 1

HCID 18652192HCID 18652192, 화합물

시약·촉매·용매 3

HCID 30318Osmium Tetroxide촉매HCID 3283Diethyl Ether용매HCID 8857Ethyl Acetate용매

실험 절차

To a mixture of 3α-acetoxy-12α-(2,2-dimethyl)butyryloxy-5β-chola-8(14),23-diene (2.5 g), osmium tetroxide (0.092 g), tert-butyl alcohol (8 ml), and water (2.3 ml) is added 4-methylmorpholine-N-oxide hydrate (0.334 g). The mixture is stirred for about 2 hours at room temperature, diluted with 20% ethyl acetate in ether and washed with aqueous sodium bisulfite. The organic solution is dried over magnesium sulfate, filtered and concentrated in vacuo to give the desired product which is used, without further treatment, for the next step.

후처리

  1. washwashed with aqueous sodium bisulfite
  2. dry with materialThe organic solution is dried over magnesium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-130da88bfc2a425db88a40b5dceb2788
출처 데이터셋
uspto-grants-1993_06
특허 번호
US05216015

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