Benzoyl Peroxide → 5-(Bromomethyl)-2,4-dimethyloxazole

HRID 1587390노트

반응식

HRID 1587390 반응식
[Br:1]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1.[CH3:27][C:28]1[O:29][C:30]([CH3:34])=[C:31]([CH3:33])[N:32]=1>ClC(Cl)(Cl)Cl>[Br:1][CH2:34][C:30]1[O:29][C:28]([CH3:27])=[N:32][C:31]=1[CH3:33]

참가 물질

5

반응물 3

HCID 7187Benzoyl PeroxideHCID 302152,4,5-TrimethyloxazoleHCID 67184N-bromobutanimide

생성물 1

HCID 223434645-(Bromomethyl)-2,4-dimethyloxazole수율 99.9%

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

To a mixture of 795 parts of dry tetrachloromethane, 40.1 parts of N-bromosuccinimide and a few parts of benzoylperoxide there were added 25 parts of 2,4,5-trimethyloxazole under a nitrogen atmosphere. The whole was stirred for 1 hour at reflux temperature. After cooling in an ice/salt bath, the reaction mixture was filtered and the filtrate was evaporated, yielding 42.7 parts (99.9%) of 5-(bromomethyl)-2,4-dimethyloxazole (interm. 9).

후처리

  1. temperatureat reflux temperature
  2. temperatureAfter cooling in an ice/salt bath
  3. filtrationthe reaction mixture was filtered
  4. customthe filtrate was evaporated

출처 및 근거

ORD 기록
ord-24750f4fdcce4c85b52e2da75277d728
출처 데이터셋
uspto-grants-1993_06
특허 번호
US05217980

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